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Screening of antiviral lead compounds against coronavirus (COVID-19; SARS-CoV-2)

VITROCELL® in vitro exposure systems for highly efficient and realistic application of aerosolized drugs to human cells of the respiratory tract under physiologic conditions

ID: 1557168
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(PresseBox) - In inhalation therapy, drugs are deposited as aerosols on cells of the respiratory tract from the nasal or lung region. For preclinical drug development, physiologically realistic in vitro cell culture models of the pulmonary epithelium and the air-blood barrier as well as from the nasal region are commercially available. Recently, these models have been refined to mimic SARS-CoV-2 infections.

In traditional in vitro testing cells are completely covered with cell culture media and it is common that drugs are dissolved in the cell culture media. This submerged exposure method represents an unphysiological drug application as the drug interacts with the cell culture media and thus the cells might receive a different dose and formulation than originally planned. Furthermore submerged lung epithelial cell cultures do not secrete protective lining fluids such as mucus or surfactant which weakens their predictive power for patients.

As a result, the submerged exposure method could lead to wrong conclusions.

The VITROCELL

Under these air/liquid conditions in vitro drug testing can more realistically mimic inhalation therapy than standard drug testing under submerged conditions, since cells can be exposed directly to the drug formulation in aerosolized form and transport of the drug across the mucus/surfactant barrier and into the cell is accounted for under physiologic conditions.

The VITROCELLprox. 3?4 minutes.

The VITROCELL

Such predictive in vitro assays may expedite the time-consuming process of preclinical and clinical testing, which is an important aspect in our urgent hunt for developing safe and efficient drugs against COVID-19.

Photo 1:

Graph 2: Air/Liquid cultivation and exposure of cells from the respiratory tract

Graph 3: How the Cloud exposure system works

Advanced in vitro exposure systems



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published by: PresseBox
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Date: 03/31/2020 - 09:19
Language: English
News-ID 1557168
Character count: 4901
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Firma: VITROCELL Systems GmbH
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Stadt: Waldkirch
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